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For establishment of cancer immunotherapy, antigen carriers are needed which have functions not only to deliver antigen into cytosol of dendritic cells (DCs), which induces antigen-specific cellular immune responses, but also to activate DCs. We previously reported cytoplasmic delivery of antigen using liposomes modified with pH-sensitive polymers such as carboxylated poly(glycidol)s or dextran. Modification...
Analyses of distances between succeeding septa throughout ontogeny of modern coleoids Sepiella japonica and Spirula spirula reveal that the first several septa (until ca. 6th–8th septa in Sepiella japonica and until ca. 2nd–3rd septa in Spirula spirula) have relatively larger septal distances than the following septa and then the distances between succeeding septa abruptly decrease at the time of...
The formation of 8-hydroxyguanine (8-OH-Gua, 7,8-dihydro-8-oxoguanine) in DNA and in the nucleotide pool results in G:C→T:A and A:T→C:G substitution mutations, respectively, due to the ability of 8-OH-Gua to pair with both C and A. In this study, shuttle plasmid DNAs containing 8-OH-Gua paired with C and A in the supF gene were transfected into human 293T cells, in which specialized DNA polymerases...
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