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Objective: N G ,N G -dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive heart failure (CHF). Methods: CHF was induced in rats by coronary...
The activity of calcium dependent (constitutive) nitric oxide synthase (cNOS) and calcium independent (inducible) iNOS determines NO release. It has been demonstrated that stimulated vascular NO release is decreased while basal release of NO is increased in CHF. However, changes in vascular cNOS and iNOS activities have not been fully described in CHF. We hypothesized that decreased stimulated...
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