Search results for: Carlos Ferreiro-Vera

Items from 1 to 9 out of 9 results

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Potentiation of cannabinoid signaling in microglia by adenosine A_2A receptor antagonists

Rafael Franco, Irene Reyes‐Resina, David Aguinaga, Alejandro Lillo, more

Glia > 67 > 12 > 2410 - 2423

Neuroprotective M2‐skewed microglia appear as promising to alter the course of neurodegenerative diseases and G protein‐coupled receptors (GPCRs) are potential targets to achieve such microglial polarization. A common feature of adenosine A_2A (A_2AR) and cannabinoid CB₂ (CB₂R) GPCRs in microglia is that their expression is upregulated in Alzheimer's disease (AD). On the one hand, CB₂R seems a target...

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Thermal desorption-ion mobility spectrometry: A rapid sensor for the detection of cannabinoids and discrimination of Cannabis sativa L. chemotypes

María del Mar Contreras, Natividad Jurado-Campos, Carolina Sánchez-Carnerero Callado, Natalia Arroyo-Manzanares, more

Sensors and Actuators B: Chemical > 2018 > 273 > C > 1413-1424

Existing analytical techniques used for the determination of cannabinoids in Cannabis sativa L. (Cannabis) plants mostly rely on chromatography-based methods. As a rapid alternative for the direct analysis of them, thermal desorption (TD)-ion mobility spectrometry (IMS) was used for obtaining spectral fingerprints of single cannabinoids from Cannabis plant extracts and from plant residues on hands...

article

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

Xavier Nadal, Carmen Río, Salvatore Casano, Belén Palomares, more

British Journal of Pharmacology > 174 > 23 > 4263 - 4276

Background and Purpose Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ⁹‐tetrahydrocannabinol have been extensively investigated, the bioactivity of Δ⁹‐tetahydrocannabinol acid (Δ⁹‐THCA) is largely unknown, despite its occurrence in different Cannabis...

article

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

Antonio Casado-Díaz, Carlos Ferreiro-Vera, Feliciano Priego-Capote, Gabriel Dorado, more

Genes & Nutrition > 2014 > 9 > 1 > 1-15

Metabolites derived from the polyunsaturated fatty acids (PUFA) may modulate the mesenchymal stromal cell (MSC) differentiation. Such cells can differentiate into different cellular types, including adipocytes and osteoblasts. Aging favors the bone marrow MSC differentiation toward the former, causing a loss of bone density associated with pathologies like osteoporosis. The omega-6 arachidonic acid...

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Global metabolomic profiling of human serum from obese individuals by liquid chromatography–time-of-flight/mass spectrometry to evaluate the intake of breakfasts prepared with heated edible oils

Carlos Ferreiro-Vera, Feliciano Priego-Capote, Mónica Calderón-Santiago, María D. Luque de Castro

Food Chemistry > 2013 > 141 > 3 > 1722-1731

The metabolic profile of human serum after intake of breakfasts prepared with different heated vegetable oils has been studied. Four oils (olive and sunflower oils, pure and enriched with natural and artificial oxidation inhibitors) were subjected to a simulated heated process prior to breakfast preparation. A metabolomics global profiling approach performed on post-basal serum samples revealed statistical...

article

Short-term comparative study of the influence of fried edible oils intake on the metabolism of essential fatty acids in obese individuals

Carlos Ferreiro-Vera, Feliciano Priego-Capote, José M. Mata-Granados, María D. Luque de Castro

Food Chemistry > 2013 > 136 > 2 > 576-584

The effect of breakfast intake of fried oils containing natural antioxidants or a synthetic autooxidation inhibitor on the metabolism of essential fatty acids focused on obese individuals. Serum levels of eicosanoids were compared in individuals before and after intake of different breakfasts. Univariate descriptive analysis was used to characterise the cohort selected for this study and multivariate...

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Targeting metabolomics analysis of the sunscreen agent 2-ethylhexyl 4-(N,N-dimethylamino)benzoate in human urine by automated on-line solid-phase extraction–liquid chromatography–tandem mass spectrometry with liquid chromatography–time-of-flight/mass spectrometry confirmation

Zacarías León-González, Carlos Ferreiro-Vera, Feliciano Priego-Capote, María Dolores Luque de Castro

Journal of Chromatography A > 2011 > 1218 > 20 > 3013-3021

The in vivo metabolism of the xenobiotic agent 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP), a UV filter commonly used in sunscreen cosmetic products, was studied by targeting metabolomics analysis in human urine. The metabolomic study involved the use of urine from male and female volunteers before and after application of an EDP-containing sunscreen cosmetic. The metabolism of EDP in urine was...

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Automated targeting analysis of eicosanoid inflammation biomarkers in human serum and in the exometabolome of stem cells by SPE–LC–MS/MS

Carlos Ferreiro-Vera, José María Mata-Granados, Feliciano Priego-Capote, José Manuel Quesada-Gómez, more

Analytical and Bioanalytical Chemistry > 2011 > 399 > 3 > 1093-1103

Inflammation is a complex cascade process involved in the pathogenesis of a number of diseases or generated as response to external or internal stimuli. Current research is focused on the development of assays for fast identification and quantitation of inflammation biomarkers. Eicosanoids are the oxidation metabolites of polyunsaturated fatty acids (mainly 20-carbon fatty acids) that play a regulation...

article

Bioaccumulation assessment of the sunscreen agent 2-ethylhexyl 4-(N,N-dimethylamino)benzoate in human semen by automated online SPE-LC-MS/MS

Zacarías León-González, Carlos Ferreiro-Vera, Feliciano Priego-Capote, María Dolores Luque de Castro

Analytical and Bioanalytical Chemistry > 2011 > 401 > 3 > 1003-1011

The proven endocrine disruption nature of the sunscreen ingredient 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP) calls for research to understand its distribution and bioaccumulation in the human body. A sensitive analytical method to determine EDP and its metabolites in human semen based on online SPE-LC-MS/MS is described. The method has been fully validated and a standard addition calibration...

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