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It is proposed that to achieve a therapeutic effect in schizophrenia patients, dopamine D 2 -receptor occupancy by antipsychotics within the striatum must exceed 60−65%. However, at high levels of D 2 -receptor occupancy, the risk of extrapyramidal symptoms (EPS) is increased. Following oral dosing of antipsychotics, peaks and troughs in plasma drug concentrations may be mirrored by...