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Little is known about ageing-related changes in the brain that affect emergence from general anaesthesia. We used young adult and aged Fischer 344 rats to test the hypothesis that ageing delays emergence from general anaesthesia by increasing anaesthetic sensitivity in the brain. Time to emergence was determined for isoflurane (1.5 vol% for 45 min) and propofol (8 mg kg−1 i.v.). The dose of isoflurane...