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This study determined whether the α4 subunit of human α4β2 neuronal nicotinic receptors is phosphorylated in situ by cyclic AMP-dependent protein kinase (PKA) or protein kinase C (PKC). To accomplish this, human cloned epithelial cells stably transfected with the human α4β2 nicotinic receptor (SH-EP1-hα4β2) were incubated with 32 P-orthophosphate to label endogenous ATP stores, and the...
These studies characterized human α4β2 neuronal nicotinic receptors stably expressed in a human epithelial cell line (SH-EP1). Receptors in transfected SH-EP1-hα4β2 cells were functional, as determined by increases in intracellular Ca2+ in response to a nicotine stimulus. Nicotine increased Fura-2 fluorescence in a concentration-dependent manner with an apparent EC50 of 2.4 μM, a response that was...
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