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The advantage of recipient hematopoiesis over that of xenogeneic donors poses a fundamental obstacle to the induction of xenograft tolerance through mixed hematopoietic chimerism. Here we explore the role of β1 integrins in maintenance of human vs porcine hematopoiesis within a human hematopoietic environment.Porcine and human c-kit + bone marrow cells were purified and cultured on human bone...
Objective. A marker for hematopoietic stem cells (HSCs) of pigs, which are considered to be the most suitable donors for clinical xenotransplantation, has not yet been identified. In this study, we examined the HSC activity of porcine c-kit + bone marrow cells (BMCs).Methods. The HSC activity of porcine c-kit + BMCs was evaluated both in vitro using colony-forming unit (CFU) and cobblestone...