Search results for: Maja Tomić

Items from 1 to 12 out of 12 results

article

Vortioxetine as an analgesic in preclinical inflammatory pain models: Mechanism of action

Marija Todorović, Ana Micov, Katarina Nastić, Maja Tomić, more

Fundamental & Clinical Pharmacology > 36 > 2 > 237 - 249

Vortioxetine is a novel atypical antidepressant with multimodal activity that has recently demonstrated efficacy against neuropathic pain. There is no published data about its analgesic properties in models characterized by peripheral inflammation and consequent pain pathway sensitization, nor data on its mechanism of antinociceptive action. This study aimed to investigate vortioxetine's antinociceptive/antihyperalgesic...

article

Topical hydrogels with escin β‐sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity

Ljiljana Djekic, Bojan Čalija, Ana Micov, Maja Tomić, more

Drug Development Research > 80 > 7 > 921 - 932

The physicochemical properties, stability, in vivo antihyperalgesic activity, and skin irritation potential of the carbomer hydrogels with the new chemical entity escin β‐sitosterol (ES) phytosome were characterized and compared with those containing escin. Physicochemical characterization of the hydrogels (performed 48 hr after preparation) included organoleptic examination, pH measurement, light...

chapter

Scaling Cu Pillars to 20um Pitch and Below: Critical Role of Surface Finish and Barrier Layers

Ting-Chia Huang, Vanessa Smet, P. M. Raj, Rick Nichols, more

2017 IEEE 67th Electronic Components and Technology Conference (ECTC) > 384 - 391

2017 IEEE 67th Electronic Components and Technology Conference (ECTC)

High-performance computing has been aggressively driving pitch and performance requirements for off-chip interconnections over the last several decades, pushing solder-based interconnections to their limits. The most leading-edge Cu pillar technology faces many fundamental challenges in scaling to pitches below 30um, in particular with stress management and increased risks of Au embrittlement as solder...

article

Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model

Radica Stepanović-Petrović, Ana Micov, Maja Tomić, Uroš Pecikoza

Psychopharmacology > 2017 > 234 > 11 > 1781-1794

Rationale We have reported that levetiracetam, a novel anticonvulsant with analgesic properties, synergizes with ibuprofen/aspirin/paracetamol in a model of diabetic painful neuropathy (DPN). Most guidelines recommend gabapentin, pregabalin, and duloxetine as first- or second-line agents for DPN. Objective We examined the effects of combination treatment of first-/second-line analgesics with levetiracetam...

article

Antihyperalgesic activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench in a rat model of inflammation

Stevan Samardžić, Maja Tomić, Uroš Pecikoza, Radica Stepanović-Petrović, more

Journal of Ethnopharmacology > 2016 > 193 > C > 652-656

Meadowsweet (Filipendula ulmaria (L.) Maxim.), and dropwort (Filipendula vulgaris Moench) flowers are traditionally used to treat various ailments, including inflammatory conditions. The aim of the present study was to validate the aforementioned ethnomedicinal claim by assessing antihyperalgesic and antiedematous activities and toxicity of orally administered lyophilized flower infusions (LFIs) of...

article

Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats

Ljiljana Djekic, Martina Martinovic, Radica Stepanović-Petrović, Ana Micov, more

European Journal of Pharmaceutical Sciences > 2016 > 92 > C > 255-265

The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated the performances of a thickening agent in physically stable HTMs at 5±3°C, 20±3°C, and 40±1°C during 6months. The results of physicochemical characterization (pH, conductivity, rheological...

article

Thelazia callipaeda—first human case of thelaziosis in Croatia

Maja Tomić Paradžik, Kristian Samardžić, Tatjana Živičnjak, Franjo Martinković, more

Wiener klinische Wochenschrift > 2016 > 128 > 5-6 > 221-223

Summary A case of the first ocular thelaziosis in a human male patient in Croatia is presented. Thelaziosis is a zoonosis caused by the nematodes of the genus Thelazia. In all, two types of the genus have been described as causes of infection in humans, Thelazia callipaeda and Thelazia californiensis. This zoonosis, called “oriental eye worm” is very rare in humans in European countries, with high...

article

Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration

Ljiljana Djekic, Martina Martinovic, Radica Stepanović‐Petrović, Maja Tomić, more

Journal of Pharmaceutical Sciences > 104 > 8 > 2501 - 2512

Nonionic surfactants (caprylocaproyl macrogol‐8 glycerides, octoxynol‐12, polysorbate‐20, and polyethylene glycol‐40 hydrogenated castor oil) (47.03%, w/w), costabilizer (poloxamer 407) (12%–20%, w/w), oil (isopropyl myristate) (5.22%, w/w), water (q.s. ad 100%, w/w), and ibuprofen (5%, w/w) were used to develop oil‐in‐water microemulsions with Newtonian flow behavior, low viscosity (from 368 ± 38...

article

Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy

Ana Micov, Maja Tomić, Uroš Pecikoza, Nenad Ugrešić, more

Pharmacological Research > 2015 > 97 > Complete > 131-142

Painful diabetic neuropathy is difficult to treat. Single analgesics often have insufficient efficacy and poor tolerability. Combination therapy may therefore be of particular benefit, because it might provide optimal analgesia with fewer adverse effects. This study aimed to examine the type of interaction between levetiracetam, a novel anticonvulsant with analgesic properties, and commonly used analgesics...

article

Antihyperalgesic and Antiedematous Activities of Bisabolol‐Oxides‐Rich Matricaria Oil in a Rat Model of Inflammation

Maja Tomić, Višnja Popović, Silvana Petrović, Radica Stepanović‐Petrović, more

Phytotherapy Research > 28 > 5 > 759 - 766

From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, α‐bisabolol oxide A (21.5%), α‐bisabolol oxide B (25.5%) and (Z)‐spiroether (cis‐en‐yn‐spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC–mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in...

article

Application of Artificial Neural Networks in Prediction of Diclofenac Sodium Release From Drug‐Modified Zeolites Physical Mixtures and Antiedematous Activity Assessment

Danina Krajišnik, Radica Stepanović‐Petrović, Maja Tomić, Ana Micov, more

Journal of Pharmaceutical Sciences > 103 > 4 > 1085 - 1094

In this study, utilization of artificial neural network (ANN) models [static—multilayer perceptron (MLP) and generalized regression neural networks and dynamic—gamma one‐layer network and recurrent one‐layer network] for prediction of diclofenac sodium (DS) release from drug‐cationic surfactant‐modified zeolites physical mixtures comprising different surfactant/drug molar ratio (0.2–2.5) was performed...

article

Bacterial colonization or infection in chronic sinusitis

Nenad Pandak, Ivana Pajić-Penavić, Alen Sekelj, Maja Tomić-Paradžik, more

Wiener klinische Wochenschrift > 2011 > 123 > 23-24 > 710-713

Summary The aim of this study was the determination of bacteria present in maxillary and ethmoid cavities in patients with chronic sinusitis and to correlate these findings with bacteria simultaneously present in their nasopharynx. The purpose of this correlation was to establish the role of bacteria found in chronically inflamed sinuses and to evaluate if the bacteria present colonized or infected...

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Search results for: Maja Tomić

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