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Oral Diseases (2011) 17, 462–468
Oral squamous cell carcinomas (SCCs) are malignant tumours that frequently invade the mandibular bone and bone invasion is a common clinical problem. Recent studies have revealed that bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. However, the cellular and molecular mechanisms of bone invasion by oral SCCs remain unclear...
Malignant melanoma in the oral cavity has a much poorer prognosis than its counterpart on the skin. Melanoma in the oral cavity is possible to invade alveolar bone. Although bone morphogenetic proteins have been suggested to be involved in the melanoma invasion, molecular mechanisms are unclear because an animal model in vivo of this event has not been established yet. In the present study, we examined...
We previously reported that osteoblasts/stromal cells are essentially involved in the activation as well as differentiation of osteoclasts through a mechanism involving cell-to-cell contact between osteoblasts/stromal cells and osteoclast precursors/osteoclasts. Osteoclast differentiation factor (ODF, also called RANKL/OPGL/TRANCE) and macrophage colony-stimulating factor (M-CSF, also called CSF-1)...
Osteoclast-like multinucleated cells (OCLs) were prepared on collagen gels in a coculture system of mouse bone marrow cells and osteoblasts, and purified by collagenase and a subsequent pronase treatment. More than 80% of the purified OCLs were found to undergo apoptotic cell death by 48 h during the culture in a culture medium containing 10% fetal bovine serum (FBS). Withdrawal of FBS from the culture...
Using co-cultures of mouse osteoblastic cells and hemopoietic cells, we have shown that osteoblastic stromal cells are prerequisite to osteoclast development through cell-cell interaction. In the present study, we developed a method for obtaining functionally active purified osteoclasts and examined whether the purified osteoclasts are capable of forming resorption pits on dentine slices without...
NF-κB is a ubiquitous transcription factor which activates a number of genes including IL-6, TNF-α, major histocompatibility complex (MHC) class 1, and adhesion molecules. These target genes of NF-κB have also been shown to be involved in the inflammatory reactions where osteoclastic bone resorption occurs. NF-κB is also known to act as a transcription factor in the action of IL-1, a well known...
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