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Selected Reaction Monitoring (SRM) is a method of choice for accurate quantitation of low-abundance proteins in complex backgrounds. This strategy is, however, sensitive to interference from other components in the sample that have the same precursor and fragment masses as the monitored transitions. We present here an approach to detect interference by using the expected relative intensity of SRM...
One of the characteristic neuropathological features of Alzheimer's disease (AD) is the deposition of amyloid β-protein (Aβ) as senile plaques in the hippocampus, and neucortex, and as congophilic angiopathy in the walls of cerebral and meningeal blood vessels. However, it is still unclear what the relationship is between the composition of soluble Aβ peptides found in cerebrospinal fluid (CSF) and...
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