Search results for: Liesbeth Boersma

Items from 1 to 20 out of 36 results

article

Developing an aftercare decision aid; assessing health professionals' and patients' preferences

Linda Klaassen, Carmen Dirksen, Liesbeth Boersma, Ciska Hoving, more

European Journal of Cancer Care > 27 > 2 > n/a - n/a

Personalising aftercare for curatively treated breast cancer patients is expected to improve patient satisfaction with care. A patient decision aid can support women in making decisions about their aftercare trajectory, but is currently not available. The aim of this study was to assess the needs of patients and health professionals with regard to an aftercare decision aid to systematically develop...

article

Heart position variability during voluntary moderate deep inspiration breath-hold radiotherapy for breast cancer determined by repeat CBCT scans

Paul van Haaren, Fiere Claassen-Janssen, Ingrid van de Sande, Liesbeth Boersma, more

Physica Medica > 2017 > 40 > C > 88-94

Voluntary moderate deep inspiration breath hold (vmDIBH) in left-sided breast cancer radiotherapy reduces cardiac dose. The aim of this study was to investigate heart position variability in vmDIBH using CBCT and to compare this variability with differences in heart position between vmDIBH and free breathing (FB).For 50 patients initial heart position with respect to the field edge (HP-FE) was measured...

article

In Regard to Vaidya et al

Icro Meattini, Liesbeth Boersma, Lorenzo Livi, Carine Kirkove, more

International Journal of Radiation Oncology*Biology*Physics > 2015 > 92 > 5 > 960-961

article

A prospective study comparing the predictions of doctors versus models for treatment outcome of lung cancer patients: A step toward individualized care and shared decision making

Cary Oberije, Georgi Nalbantov, Andre Dekker, Liesbeth Boersma, more

Radiotherapy and Oncology > 2014 > 112 > 1 > 37-43

Decision Support Systems, based on statistical prediction models, have the potential to change the way medicine is being practiced, but their application is currently hampered by the astonishing lack of impact studies. Showing the theoretical benefit of using these models could stimulate conductance of such studies. In addition, it would pave the way for developing more advanced models, based on genomics,...

article

‘Rapid Learning health care in oncology’ – An approach towards decision support systems enabling customised radiotherapy’

Philippe Lambin, Erik Roelofs, Bart Reymen, Emmanuel Rios Velazquez, more

Radiotherapy and Oncology > 2013 > 109 > 1 > 159-164

An overview of the Rapid Learning methodology, its results, and the potential impact on radiotherapy.Rapid Learning methodology is divided into four phases. In the data phase, diverse data are collected about past patients, treatments used, and outcomes. Innovative information technologies that support semantic interoperability enable distributed learning and data sharing without additional burden...

article

Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

Kaouthar Khanfir, Adel Kallel, Sylviane Villette, Yazid Belkacémi, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 82 > 5 > 2118-2124

Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC.Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy...

article

Forward Intensity-Modulated Radiotherapy Planning in Breast Cancer to Improve Dose Homogeneity: Feasibility of Class Solutions

Heike Peulen, Bianca Hanbeukers, Liesbeth Boersma, Angela van Baardwijk, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 82 > 1 > 394-400

To explore forward planning methods for breast cancer treatment to obtain homogeneous dose distributions (using International Commission on Radiation Units and Measurements criteria) within normal tissue constraints and to determine the feasibility of class solutions.Treatment plans were optimized in a stepwise procedure for 60 patients referred for postlumpectomy irradiation using strict dose constraints:...

article

Microscopic Disease Extension in Three Dimensions for Non–Small-Cell Lung Cancer: Development of a Prediction Model Using Pathology-Validated Positron Emission Tomography and Computed Tomography Features

Judith van Loon, Christian Siedschlag, Joep Stroom, Hans Blauwgeers, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 82 > 1 > 448-456

One major uncertainty in radiotherapy planning of non–small-cell lung cancer concerns the definition of the clinical target volume (CTV), meant to cover potential microscopic disease extension (MDE) around the macroscopically visible tumor. The primary aim of this study was to establish pretreatment risk factors for the presence of MDE. The secondary aim was to establish the impact of these factors...

article

The impact of microscopic disease on the tumor control probability in non-small-cell lung cancer

Christian Siedschlag, Liesbeth Boersma, Judith van Loon, Maddalena Rossi, more

Radiotherapy and Oncology > 2011 > 100 > 3 > 344-350

To indicate which clinical target volume (CTV) margin (if any) is needed for an adequate treatment of non-small-cell lung cancer (NSCLC) using either 3D conformal or stereotactic radiotherapy, taking the distribution of the microscopic disease extension (MDE) into account.On the basis of the linear-quadratic biological model, a Monte-Carlo simulation was used to study the impact of MDE and setup deviations...

article

Therapeutic implications of molecular imaging with PET in the combined modality treatment of lung cancer

Judith van Loon, Angela van Baardwijk, Liesbeth Boersma, Michel Öllers, more

Cancer Treatment Reviews > 2011 > 37 > 5 > 331-343

Molecular imaging with PET, and certainly integrated PET-CT, combining functional and anatomical imaging, has many potential advantages over anatomical imaging alone in the combined modality treatment of lung cancer. The aim of the current article is to review the available evidence regarding PET with FDG and other tracers in the combined modality treatment of locally advanced lung cancer. The following...

article

Selective Nodal Irradiation on Basis of 18FDG-PET Scans in Limited-Disease Small-Cell Lung Cancer: A Prospective Study

Judith van Loon, Dirk De Ruysscher, Rinus Wanders, Liesbeth Boersma, more

International Journal of Radiation Oncology, Biology, Physics > 2010 > 77 > 2 > 329-336

To evaluate the results of selective nodal irradiation on basis of ¹⁸ F-deoxyglucose positron emission tomography (PET) scans in patients with limited-disease small-cell lung cancer (LD-SCLC) on isolated nodal failure.A prospective study was performed of 60 patients with LD-SCLC. Radiotherapy was given to a dose of 45 Gy in twice-daily fractions of 1.5 Gy, concurrent with carboplatin and etoposide...

article

E4. Current clinical issues in breast cancer

Philip Poortmans, Albert Biete Sola, Liesbeth Boersma, Youlia Kirova, more

EJC Supplements > 2010 > 8 > 3 > 9-10

article

18FDG-PET-CT in the follow-up of non-small cell lung cancer patients after radical radiotherapy with or without chemotherapy: An economic evaluation

Judith van Loon, Janneke P.C. Grutters, Rinus Wanders, Liesbeth Boersma, more

European Journal of Cancer > 2010 > 46 > 1 > 110-119

The optimal follow-up strategy of non-small cell lung cancer (NSCLC) patients after curative intent therapy is still not established. In a recent prospective study with 100 patients, we showed that a FDG-PET-CT 3 months after radiotherapy (RT) could identify progression amenable for curative treatment in 2% (95% confidence interval (CI): 1–7%) of patients, who were all asymptomatic. Here, we report...

article

Can we optimize chemo-radiation and surgery in locally advanced stage III non-small cell lung cancer based on evidence from randomized clinical trials? A hypothesis-generating study

Dirk De Ruysscher, Cary Dehing, Søren M. Bentzen, Ruud Houben, more

Radiotherapy and Oncology > 2009 > 93 > 3 > 389-395

Improved local tumor control (LC) improves survival of patients with non-small cell lung cancer (NSCLC). We estimated the capability of surgical and non-surgical options to improve LC further in this disease.Eligible studies were phase III trials reporting 2-year survival data as well as the incidence of LC and/or distant metastases. Effect estimates, as well as the statistical uncertainty of these,...

article

Customized Computed Tomography-Based Boost Volumes in Breast-Conserving Therapy: Use of Three-Dimensional Histologic Information for Clinical Target Volume Margins

Bianca Hanbeukers, Jacques Borger, Piet van den Ende, Fred van der Ent, more

International Journal of Radiation Oncology, Biology, Physics > 2009 > 75 > 3 > 757-763

To determine the difference in size between computed tomography (CT)-based irradiated boost volumes and simulator-based irradiated volumes in patients treated with breast-conserving therapy and to analyze whether the use of anisotropic three-dimensional clinical target volume (CTV) margins using the histologically determined free resection margins allows for a significant reduction of the CT-based...

article

The influence of the use of CT-planning on the irradiated boost volume in breast conserving treatment

Shafak Al Uwini, Ninja Antonini, Philip M. Poortmans, Liesbeth Boersma, more

Radiotherapy and Oncology > 2009 > 93 > 1 > 87-93

The purpose of this study was to investigate the effect of CT-based delineation and planning on the irradiated boost volume. For this specific purpose we used the data as derived from 2 prospective phase III randomised trials.Data from 1331 patients (⩽50 years) were analyzed with a reported boost volume from a simulation-based treatment plan (EORTC boost vs no boost trial, n=922), and a CT-scan-based...

article

Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy 18Fluorodeoxyglucose-PET-CT scan

Hugo J.W.L. Aerts, Angela A.W. van Baardwijk, Steven F. Petit, Claudia Offermann, more

Radiotherapy and Oncology > 2009 > 91 > 3 > 386-392

Non-small cell lung cancer (NSCLC) tumours are mostly heterogeneous. We hypothesized that areas within the tumour with a high pre-radiation ¹⁸ F-deoxyglucose (FDG) uptake, could identify residual metabolic-active areas, ultimately enabling selective-boosting of tumour sub-volumes.Fifty-five patients with inoperable stage I–III NSCLC treated with chemo-radiation or with radiotherapy alone were...

article

High-dose radiotherapy or concurrent chemo-radiation in lung cancer patients only induces a temporary, reversible decline in QoL

Madelon Pijls-Johannesma, Ruud Houben, Liesbeth Boersma, Janneke Grutters, more

Radiotherapy and Oncology > 2009 > 91 > 3 > 443-448

Aggressive radiotherapy or concurrent chemo-radiation therapy for lung cancer leads to a high incidence of severe, mostly esophageal, toxicity. The purpose of this study was to investigate the evolution of quality of life (QoL) in patients with lung cancer, selected for curative radiotherapy (RT) or chemo-RT.Seventy-five lung cancer patients completed a longitudinal the EORTC QLQ-C30 and LC13. Linear...

article

Increased 18F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): A prospective pilot study

Dirk De Ruysscher, Ans Houben, Hugo J.W.L. Aerts, Cary Dehing, more

Radiotherapy and Oncology > 2009 > 91 > 3 > 415-420

As Radiation-Induced Lung Toxicity (RILT) is dose-limiting for radiotherapy (RT) of lung cancer and current parameters are only moderately associated with RILT, we sought for novel parameters associated with RILT.In this prospective study, FDG-PET-CT scans were taken on days 0, 7 and 14 after initiation of high-dose RT in 18 patients with stage III non-small cell lung cancer. The maximal Standardized...

article

Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer

Dirk De Ruysscher, Cary Dehing, Shipeng Yu, Rinus Wanders, more

Radiotherapy and Oncology > 2009 > 91 > 3 > 353-359

To determine what the influence is of dyspnea (CTCAE3.0) before high-dose radiotherapy (RT) on the incidence and severity of subsequent lung toxicity in patients with non-small cell lung cancer (NSCLC).In 197 patients with stage I-III NSCLC maximal dyspnea scores (CTCAE3.0) were obtained prospectively at three time periods: before RT, the first 6 months post-RT and 6–9 months post-RT. Only patients...

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Search results for: Liesbeth Boersma

Developing an aftercare decision aid; assessing health professionals' and patients' preferences

Heart position variability during voluntary moderate deep inspiration breath-hold radiotherapy for breast cancer determined by repeat CBCT scans

In Regard to Vaidya et al

A prospective study comparing the predictions of doctors versus models for treatment outcome of lung cancer patients: A step toward individualized care and shared decision making

‘Rapid Learning health care in oncology’ – An approach towards decision support systems enabling customised radiotherapy’

Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

Forward Intensity-Modulated Radiotherapy Planning in Breast Cancer to Improve Dose Homogeneity: Feasibility of Class Solutions

Microscopic Disease Extension in Three Dimensions for Non–Small-Cell Lung Cancer: Development of a Prediction Model Using Pathology-Validated Positron Emission Tomography and Computed Tomography Features

The impact of microscopic disease on the tumor control probability in non-small-cell lung cancer

Therapeutic implications of molecular imaging with PET in the combined modality treatment of lung cancer

Selective Nodal Irradiation on Basis of 18FDG-PET Scans in Limited-Disease Small-Cell Lung Cancer: A Prospective Study

E4. Current clinical issues in breast cancer

18FDG-PET-CT in the follow-up of non-small cell lung cancer patients after radical radiotherapy with or without chemotherapy: An economic evaluation

Can we optimize chemo-radiation and surgery in locally advanced stage III non-small cell lung cancer based on evidence from randomized clinical trials? A hypothesis-generating study

Customized Computed Tomography-Based Boost Volumes in Breast-Conserving Therapy: Use of Three-Dimensional Histologic Information for Clinical Target Volume Margins

The influence of the use of CT-planning on the irradiated boost volume in breast conserving treatment

Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy 18Fluorodeoxyglucose-PET-CT scan

High-dose radiotherapy or concurrent chemo-radiation in lung cancer patients only induces a temporary, reversible decline in QoL

Increased 18F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): A prospective pilot study

Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer

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