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The innate immune response is a finely tuned reaction of balanced positive and negative signals that ensure the response is appropriate to defend the host – induction of appropriate effector molecules, short duration, and appropriate strength. An imbalanced response can lead to acute and chronic inflammatory diseases.A relatively new level of control of signaling in biological processes occurs via...
The mood stabilizing agents lithium chloride (LiCl) and sodium valproate (VPA) have recently gained interest as potential neuroprotective therapeutics. However, exploitation of these therapeutic applications is hindered by both a lack of molecular understanding of the mode of action, and a number of sub-optimal properties, including a relatively small therapeutic window and variable patient response...
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