Search results for: Asma Kheirollahi

Items from 1 to 8 out of 8 results

article

Investigating the role of loop 131–140 in activity and thermal stability of chondroitinase ABC I

Asma Kheirollahi, Khosro Khajeh, Abolfazl Golestani

International Journal of Biological Macromolecules > 2018 > 116 > C > 811-816

Previously, we attempted to improve the thermostability of chondroitinase ABC I by substituting proline in flexible sites and successfully obtained a mutant; E138P, with increased thermostability (Kheirollahi et al., 2017). In this study, we focused on the role of Glu138 in activity and stability of the enzyme using its further mutation to Ala, Lys, and Asp. Moreover, we coupled the two mutations...

article

Calcium and TNFα additively affect the chondroitinase ABC I activity

Molood Bagherieh, Asma Kheirollahi, Mohammad E Shahaboddin, Khosro Khajeh, more

International Journal of Biological Macromolecules > 2017 > 103 > C > 1201-1206

Experimental models have repeatedly shown the therapeutic potential of cABC I in spinal cord injury (SCI) by degrading chondroitin sulfate proteoglycans that hinder neurite outgrowth. Following SCI, some molecules are released from injured cells. This study is designed to determine the effects of some of these molecules at the SCI loci on activity, stability and structure of wild type and Q140A variant...

article

The effect of melatonin on gene expression of calcitonin gene-related peptide and some proinflammatory mediators in patients with pure menstrual migraine

Mohammad Ansari, Azam Karkhaneh, Asma Kheirollahi, Solaleh Emamgholipour, more

Acta Neurologica Belgica > 2017 > 117 > 3 > 677-685

The neuropeptide calcitonin gene-related peptide (CGRP), a potent vasoactive and a marker of trigeminal inflammation, has been considered as an important mediator in various types of migraine such as pure menstrual migraine. Earlier studies have shown that CGRP can modulate the synthesis and release of other inflammatory factor including nitric oxide (NO) and interleukin-1beta (IL-1β) from trigeminal...

article

Rigidifying flexible sites: An approach to improve stability of chondroitinase ABC I

Asma Kheirollahi, Khosro Khajeh, Abolfazl Golestani

International Journal of Biological Macromolecules > 2017 > 97 > C > 270-278

The stability of chondroitin ABC lyase I (cABC I) at physiological temperature is one of the current obstacles to its clinical application. In this study, we used a protein engineering approach; rigidify flexible sites, to improve stability of cABC I. B-factor analysis showed a flexible loop at the N-terminal domain of cABC I which may be involved in its thermal instability and five residues in this...

article

Apaf-1: Regulation and function in cell death

Raheleh Shakeri, Asma Kheirollahi, Jamshid Davoodi

Biochimie > 2017 > 135 > C > 111-125

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or unnecessary cells in multicellular organisms. Various types of intracellular stress trigger apoptosis by induction of cytochrome c release from mitochondria into the cytosol. Apoptotic protease activating factor-1 (Apaf-1) is a key molecule in the intrinsic or mitochondrial pathway of apoptosis, which oligomerizes...

article

Synthesis and Anti‐Cancer Activity Evaluation of New Dimethoxylated Chalcone and Flavanone Analogs

Shima H. M. E. Ketabforoosh, Asma Kheirollahi, Maliheh Safavi, Nasim Esmati, more

Archiv der Pharmazie > 347 > 11 > 853 - 860

A novel series of chalcones and flavanones discriminated by the presence of a 3,4‐dimethoxyphenyl moiety in their structures were synthesized as anti‐cancer agents. The cytotoxicity evaluation of the analogs against the MCF‐7, MDA‐MB‐231 (human breast cancer), and SK‐N‐MC (human neuroblastoma) cell lines demonstrated that the introduction of a halogen on the 3,4‐dimethoxyphenyl part of both series...

article

Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines

Asma Kheirollahi, Mahboobeh Pordeli, Maliheh Safavi, Sara Mashkouri, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2014 > 387 > 12 > 1199-1208

With the aim of discovering potential cytotoxic agents, a series of benzochromene derivatives were screened for their cytotoxic activity against seven human cancer cell lines by standard 3-(4, 5-dimethyl thiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay. Apoptosis, as the mechanism of cell death, was investigated morphologically by acridine orange/ethidium bromide staining and cell surface expression...

article

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs

Mandana Banimustafa, Asma Kheirollahi, Maliheh Safavi, Sussan Kabudanian Ardestani, more

European Journal of Medicinal Chemistry > 2013 > 70 > Complete > 692-702

A series of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones 5 were designed as new heterocyclic analogs of combretastatin A-4 (CA-4). Indeed, the olefinic core structure of CA-4 has been replaced by 2(3H)-thiazole thione. The general synthetic strategy to prepare compounds 5 was based on the cyclocondensation reaction between triethylammonium N-(trimethoxyphenyl)dithiocarbamate and appropriate phenacyl...

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Search results for: Asma Kheirollahi

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