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Coagulation is a critical component in the progression of liver disease. Identification of key molecules involved in the intrahepatic activation of coagulation (IAOC) will be instrumental in the development of effective therapies against liver disease. Using a mouse model of concanavalin A (ConA)‐induced hepatitis, in which IAOC plays an essential role in causing liver injury, we uncovered a procoagulant...
Application of a voltage ramp can result in denaturation of dsDNA and strand separation. We show that the potential at which half of the surface immobilised duplexes denature (the melting potential, E m ) directly correlates with the calculated nearest neighbour and experimental melting temperatures; T m , for a duplex is solution. The results demonstrate that the electrochemical melting...
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