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Retinal ganglion cell (RGC) axons are topographically ordered in the optic tract according to their retinal origin. In zebrafish dackel (dak) and boxer (box) mutants, some dorsal RGC axons missort in the optic tract but innervate the tectum topographically. Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis. Both genes...
Phenotypic analysis of both zebrafish and mouse has shown that fibroblast growth factor 8 (FGF8) is required for many developmental decisions. To further our understanding of the FGF8 signaling process, we sought to identify new transcriptional targets of the pathway. Here, we propose that two zebrafish ETS genes, pea3 and erm, are general targets of FGF8 signaling, based upon the following observations:...
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