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Phencyclidine and ketamine (but not other NMDA channel blockers, such as memantine) produce psychotomimetic effects. Since unlike memantine, phencyclidine-like compounds show no significant affinity at 5-HT 3 receptors, we investigated if behavioral effects of ketamine could be reduced by 5HT 3 receptor blockade. Ketamine (3–40 mg/kg) produced ataxia, stereotypes and diminished exploratory...
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