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Estrogen receptor (ER) has two subtypes, ERα and ERβ. In this study, age-related changes of hippocampal gene expressions of ERα and ERβ were examined in senescence-accelerated mouse (SAM) with real-time reverse transcription-polymerase chain reaction (RT-PCR) technique, in an attempt to explore the relationship between estrogen receptor expression and age-related deficit of learning and memory in...