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One of the major problems of the methodology of translational research is to find biomarkers that serve as indicators of treatment response.The aim was to study the dynamics of biochemical markers in the process of combined antipsychotics and electroconvulsive therapy.Present study was conducted in 34 patients with treatment-resistant schizophrenia (31.6±9.4 years old) that underwent combined ECT...
Electroconvulsive therapy (ECT) is considered an effective and safe treatment. However, the possibility of cognitive adverse effects has raised a question about neuronal damage. Neuron-specific enolase (NSE) and S100b protein (S100b) were measured to determine whether ECT induces neuronal injury or glial activation. C-reactive protein (CRP), creatine phosphokinase (CPK) and CPK-MB levels were also...
The enzyme telomerase plays a crucial role in cellular proliferation and tumorigenesis. By adding hexameric repeats to chromosome ends, it prevents telomeric loss and, thus, entry into senescence. Recent data suggest that expression of the human telomerase reverse transcriptase subunit (hTERT) represents the limiting factor for telomerase activity. To gain an insight into the mechanisms regulating...
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