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Activating mutations in GNAQ and GNA11, encoding members of the Gα q family of G protein α subunits, are the driver oncogenes in uveal melanoma, and mutations in Gq-linked G protein-coupled receptors have been identified recently in numerous human malignancies. How Gα q and its coupled receptors transduce mitogenic signals is still unclear because of the complexity of signaling events...
Activation of P2Y 1 and P2Y 12 receptors, through secreted ADP that is stimulated by agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet activation. P2X 1 receptors also participate in platelet shape change and potentiation of calcium mobilization. The cloning of the P2Y 12 receptor and its subsequent knockout in mice promises...
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