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Sex steroid hormones act on developing neural circuits regulating the hypothalamic‐pituitary‐gonadal axis and are involved in hormone‐sensitive behaviours. These hormones act mainly via nuclear receptors, such as oestrogen receptor (ER)‐α and androgen receptor (AR). By using immunohistochemistry, we analysed the expression level of ERα and AR throughout perinatal life [at embryonic (E) day 19 and...
The SP/KLF transcription factor family contains over 25 members sharing a DNA-binding domain composed of three zinc fingers of the C 2 H 2 type. We previously identified the sixth member of the SP subfamily (Sp6). The 5′ end of the Sp6 transcript was not cloned and was predicted bioinformatically. A mouse molar tooth cDNA was then isolated differing from the Sp6 sequence by its 5′...
This work shows that the proximal promoter of the mouse Afp gene contains a Ku binding site and that Ku binding is associated with down-regulation of the transcriptional activity of the Afp promoter. The Ku binding site is located in a segment able to adopt a peculiar structured form, probably a hairpin structure. Interestingly, the structured form eliminates the binding sites of the positive transcription...
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