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Abstract.Objective and design: JTE-607, a multiple cytokine inhibitor, was evaluated in lipopolysaccharide (LPS)-induced acute lung injury in rats in vivo and in vitro.Materials and methods: LPS instillation into airways of rats was performed. JTE-607 at 3-30 mg/kg and dexamethasone at 3 mg/kg were administered intravenously at 10 min and 0 min for JTE-607, and 60 min for dexamethasone prior to the...
Intracellular localization of p-O-β-d-glucosylbenzoic acid (PHBOG) and its aglycone, p-hydroxybenzoic acid (PHB), a key intermediate of shikonin biosynthesis, was investigated in Lithospermum erythrorhizon cell cultures. The glucoside, which is characteristically accumulated in shikonin-free Lithospermum cell cultures, proved to be localized mainly in the vacuoles of cells. p-Hydroxybenzoate glucosyltransferase,...
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