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Abstract
Dysferlin is an integral membrane protein of the transverse tubules of skeletal muscle that is mutated or absent in limb girdle muscular dystrophy 2B and Miyoshi myopathy. Here we examine the role of dysferlin's seven C2 domains, C2A through C2G, in membrane repair and Ca2+ release, as well as in targeting dysferlin to the transverse tubules of skeletal muscle. We report that deletion of...
The semantic bootstrapping hypothesis proposes that children acquire their native language through exposure to sentences of the language paired with structured representations of their meaning, whose component substructures can be associated with words and syntactic structures used to express these concepts. The child’s task is then to learn a language-specific grammar and lexicon based on (probably...
We present a novel approach for improving communication success between users of speech-to-speech translation systems by automatically detecting errors in the output of automatic speech recognition (ASR) and statistical machine translation (SMT) systems. Our approach initiates system-driven targeted clarification about errorful regions in user input and repairs them given user responses. Our system...
This paper addresses the problem of detecting words that are out-of-vocabulary (OOV) for a speech recognition system to improve automatic speech translation. The detection system leverages confidence prediction techniques given a confusion network representation and parsing with OOV word tokens to identify spans associated with true OOV words. Working in a resource-constrained domain, we achieve OOV...
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