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One of the major innate‐like lymphocyte populations enriched in the liver consists of natural killer T (NKT) cells, which recognize self and foreign lipid antigens presented by the nonpolymorphic class I major histocompatibility complex–like molecule CD1d. NKT cells express natural killer cell markers as well as T cell receptors (TCRs) and can be classified into 2 categories: type I NKT cells use...
We have identified and characterized the tissue distribution of the antigen recognized by a novel monoclonal antibody (mAb) 1B10, raised against an activated γδ T cell clone. Immunohistochemistry of tissue sections, analysis of single cell suspensions by flow cytometry revealed that mAb 11110 weakly reacted with 6% of normal human peripheral blood mononuclear cells (PBMC). After 5-6 days of in vitro...
CD8 + T cells control immune responses, and recent studies suggest that this regulation is, in part, specifically directed towards TCR structures expressed by CD4 + cells. To develop a system to study the role of the TCR in regulatory interactions, we isolated clones of CD4 + cells expressing identified TCR Vβ chains. These CD4 + clones were used to stimulate and expand...
Interactions mediated by TCRs expressed on different T cell subsets may play a role in immunoregulation. To investigate this idea, we studied the regulation of superantigen-induced TCR Vβ-restricted responses. We asked whether the in vivo regulation of CD4 + Vβ8 + T cells following SEB injection is controlled by CD8 + T cells. We found that in mice deficient in CD8 + ...
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