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Lactate is a key metabolite for the normal occurrence of spermatogenesis. In the testis, lactate is produced by the Sertoli cells and transported to germline cells. Monocarboxylate transporters (MCTs) are key players in that process. Among the family of MCTs, MCT1 is at least partly responsible for lactate uptake by the germ cells. We aimed to perform a first assessment of the role of MCT1 in male...
The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8αβ coreceptor to the thymocyte surface. We show that immature CD4 + CD8 + double-positive thymocytes bind MHCI tetramers more avidly than mature CD8 single-positive...
To test whether kinesin-II is important for transport in the mammalian photoreceptor cilium, and to identify its potential cargoes, we used Cre-loxP mutagenesis to remove the kinesin-II subunit, KIF3A, specifically from photoreceptors. Complete loss of KIF3A caused large accumulations of opsin, arrestin, and membranes within the photoreceptor inner segment, while the localization of α-transducin was...
T lymphocyte activation evokes distinct changes in cell surface O-glycans. CD8 + T cells undergo an elimination of sialic acid on core 1 O-glycans and an induction of core 2 O-glycans until either apoptotic death or differentiation into memory cells. We find that the ST3Gal-l sialyltransferase is required for core 1 O-glycan sialylation and its deficiency induces core 2 O-glycan biosynthesis...
Alpha-mannosidase-II (αM-II) catalyzes the first committed step in the biosynthesis of complex asparagine- linked (N-linked) oligosaccharides (N-glycans). Genetic deficiency of αM-II should abolish complex N-glycan production as reportedly does inhibition of αM-II by swainsonine. We find that mice lacking a functional αM-II gene develop a dyserythropoietic anemia concurrent with loss of erythrocyte...
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