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In article number 1700705, Aram J. Chung and co‐workers report a novel inertial microfluidic cell stretcher capable of characterizing large populations of single‐cell deformability near real‐time in a fully automated manner. This study opens up a new path to practically measure large populations of single‐cell quantitative mechanical properties on‐the‐fly with high statistical significances, enabling...
Mechanical biomarkers associated with cytoskeletal structures have been reported as powerful label‐free cell state identifiers. In order to measure cell mechanical properties, traditional biophysical (e.g., atomic force microscopy, micropipette aspiration, optical stretchers) and microfluidic approaches were mainly employed; however, they critically suffer from low‐throughput, low‐sensitivity, and/or...
Current preclinical evaluations of nanoparticle taxanes have focused on the effect of nanoparticle size and shape on the efficacy and toxicity. It is generally assumed that nanoparticle therapeutics have the same cellular response on tumor and normal cells as their small molecule counterparts. Here, we show that nanoparticle taxanes can mediate cellular effects distinct from that of small molecule...
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