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Progesterone is an anticonvulsant neurosteroid. It is reduced by the unidirectional enzyme 5α-reductase to 5α-dihydroprogesterone (DHP) and subsequently reduced by the bidirectional enzyme 3α,5α- hydroxysteroidoxidoreductase to 3α,5α-tetrahydroprogesterone (THP, also called “allopregnanolone”). Progesterone, DHP and THP have protective effects in models of traumatic brain injury, and slows epileptogenesis...
Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been reported to raise seizure thresholds. The purpose of the present study was to test the acute anticonvulsant effects of unesterified DHA in rats, using the maximal pentylenetetrazol (PTZ) seizure model, and also to examine DHA incorporation and distribution into blood serum total lipids and brain phospholipids and unesterified fatty acids...
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