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Prdx6 is a multi-functional enzyme that expresses peroxidase, phospholipase A2 (PLA2) and LPC acyltransferase activities. While the three activities of Prdx6 contribute to either the scavenging of lipid hydroperoxides or to the repair of peroxidized membranes, the PLA2 activity of Prdx6 (aiPLA2) is also required for Nox2 activation in pulmonary microvascular cells (PMVECs), alveolar macrophages and...