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We present an approach for analyzing the morphology of anatomical structures of the brain, which uses an elastic transformation to normalize brain images into a reference space. The properties of this transformation are used as a quantitative description of the size and shape of brain structures; inter-subject comparisons are made by comparing the transformations themselves. The utility of...
We propose an automated method to segment cortical necrosis from brain FLAIR-MR Images. Cortical necrosis are regions of dead brain tissue in the cortex caused by cerebrovascular disease (CVD). The accurate segmentation of these regions is difficult as their intensity patterns are similar to the adjoining cerebrospinal fluid (CSF). We generate a model of normal variation using MR scans of healthy...
MRI has proven highly sensitive in detecting subtle abnormalities in cortical and subcortical brain parenchyma. While some of these abnormalities are associated with known neurologic disorders, many are unexpected or incidental. White matter lesions (WMLs), ventricular enlargement (VE), and sulcal widening (SW) are common findings in persons over age 50. Although these structural abnormalities...
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