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Tolerance represents a critical component of addiction. The large-conductance calcium- and voltage-activated potassium channel (BK) is a well-established alcohol target, and an important element in behavioral and molecular alcohol tolerance. We tested whether microRNA, a newly discovered class of gene expression regulators, plays a role in the development of tolerance. We show that in adult mammalian...
A procedure to calculate probability limits for the inference that the absence of a taxon from a woodrat (Neotoma) midden implies absence from the paleolandscape uses paired samples of modern vegetation communities and paired samples of paleocommunities. Assumptions are: (1) each member of a sample pair is an independent measure of the same vegetation assemblage; (2) behavioral patterns of woodrats...
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