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Individuals 50–64 years of age have reduced immune responses to influenza vaccines. The current study examined whether a high-dose inactivated trivalent influenza vaccine (IIV3-HD) might improve immune responses over a standard-dose inactivated influenza vaccine (IIV3-SD) in this age group.This was a multicenter, observer-blinded, randomized, active-controlled phase II trial. Adults 50–64 years of...