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Excitatory amino acid transporter 2 (EAAT2) belongs to a family of Na + dependent glutamate transporters that maintain a low synaptic concentration of glutamate by removing glutamate from the synaptic cleft into astroglia and neurons. EAAT2 activity depends on Na + and K + gradients generated by Na + /K + ATPase and ATP. Hexokinase 1 (HK1), an initial enzyme...