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Stimulation of DNA and protein synthesis in brown preadipocytes by 1 μM neokyotorphin in serum-containing media was comparable with the effect of 1 μM norepinephrine. In serum-free medium a decrease and a shift of the maximal effect to lower concentration of neokyotorphin were observed. Kyotorphin had no effect on cell proliferation in either medium; however, 0.01–1 μM kyotorphin inhibited the cell...