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Morphine stimulates nitric oxide (NO) release in human endothelial cells. To determine whether this mechanism also occurs in invertebrates, the musselMytilus edulis was studied. Exposure of excised ganglia to morphine for 24 h resulted in a significant dose-dependent decrease in rnicroglial egress that was naloxone sensitive. In coincubating the excised ganglia with morphine and the nitric oxide synthase...