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Innate sensing of viral infection and the subsequent activation of signaling pathways are essential for an effective antiviral immune response. Retinoic acid-inducible gene-I (RIG-I; also called DDX58) and melanoma differentiation-associated gene 5 (MDA5; also known as IFIH1) have emerged as key cytosolic sensors for the detection of RNA viruses. Upon viral RNA binding, the N-terminal caspase recruitment...
RIG-I and MDA5 have emerged as key cytosolic sensors for the detection of RNA viruses and lead to antiviral interferon (IFN) production. Recent studies have highlighted the importance of posttranslational modifications for controlling RIG-I antiviral activity. However, the regulation of MDA5 signal-transducing ability remains unclear. Here, we show that MDA5 signaling activity is regulated by a dynamic...
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