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Epidermal growth factor receptors (EGFR, HER2 and HER3) activate signal transduction pathways involved in cancer proliferation, apoptosis, differentiation, metastasis and angiogenesis. Their overexpression and activation is associated with the unfavourable prognosis of cancer patients, therefore they are attractive targets for cancer therapy. As a result of the development of drug resistance, therapeutic...
Although cancer stem-like cells (CSCs) are rare, they can enter a non-proliferative or dormant state and resist therapy. Furthermore, quiescent CSCs are responsible for metastases that can appear after curative surgical treatment of a primary tumor. Because of drug resistance of CSCs, the development of novel therapies is urgently required that specifically target CSCs. The aim of the present study...
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