Epidermal growth factor receptors (EGFR, HER2 and HER3) activate signal transduction pathways involved in cancer proliferation, apoptosis, differentiation, metastasis and angiogenesis. Their overexpression and activation is associated with the unfavourable prognosis of cancer patients, therefore they are attractive targets for cancer therapy. As a result of the development of drug resistance, therapeutic monoclonal antibodies and small molecule tyrosine kinase inhibitors directed against EGFR family members may fail, with fatal consequences for cancer patients. Medicinal plants have raised considerable interest in recent years as valuable resources to develop novel treatment therapies targeting EGFRs and their downstream signal transduction pathways. The present chapter gives an overview of phytochemicals, medicinal plants and herbal mixtures derived from Chinese medicine that inhibit these signalling routes. Inhibitors have been described that down‐regulate the mRNA or protein expression of EGFR, HER2 or HER3, or inhibit the phosphorylation of these receptors and/or their downstream signalling kinases. Importantly, not only in vitro but also in vivo experiments have been published, indicating that natural products are also active in living animals, bringing this research concept closer to clinical applicability.