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Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tissues. Pancreatic organoids can be rapidly generated from resected tumors and biopsies,...
Inflammation has many faces, most commonly observed as an acute reaction in response to pathogen or another insult, or a chronic phase, accompanying chronic infection and chronic remittent inflammatory disease, such as inflammatory bowel disease [1]. Yet, there is another type of smoldering inflammation, harder to notice or monitor, which appears to underlie some of the major human diseases, cancer,...
Senescence, perceived as a cancer barrier, is paradoxically associated with inflammation, which promotes tumorigenesis. Here, we characterize a distinct low-grade inflammatory process in stressed epithelium that is related to para-inflammation; this process either represses or promotes tumorigenesis, depending on p53 activity. Csnk1a1 (CKIα) downregulation induces a senescence-associated inflammatory...
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