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In the human brain, pLG72 interacts with the flavoenzyme d‐amino acid oxidase (hDAAO), which is involved in catabolism of d‐serine, a co‐agonist of N‐methyl‐d‐aspartate receptors (NMDAR). Here, we investigated the wild‐type pLG72, the R30K variant associated with schizophrenia susceptibility, and the K62E variant. The protein conformation, oligomeric state, ligand‐, and hDAAO‐binding properties are...
The human flavoenzyme d‐amino acid oxidase (hDAAO) degrades the NMDA‐receptor modulator d‐serine in the brain. Although hDAAO has been extensively characterized, little is known about its main modulator pLG72, a small protein encoded by the primate‐specific gene G72 that has been associated with schizophrenia susceptibility. pLG72 interacts with neosynthesized hDAAO, promoting its inactivation and...
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