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Mechanisms by which bone microdamage triggers repair response are not completely understood. It has been shown that calcium efflux ([Ca 2+ ] E ) occurs from regions of bone undergoing microdamage. Such efflux has also been shown to trigger intracellular calcium signaling ([Ca 2+ ] I ) in MC3T3-E1 cells local to damaged regions. Voltage-gated calcium channels (VGCCs)...