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The yellow Iranian scorpion Odontobuthus doriae can cause fatal envenoming, but its mechanism of action is unclear. One of the reported manifestations of envenoming is moderate to severe involuntary tremor of skeletal muscle. In order to understand better the mechanism of action of this venom on skeletal muscle function, we examined the effects of the venom in vitro on chick biventer cervicis (CBC)...
Dendrotoxins are 57-60 residue proteins isolated from venoms of mamba snakes, Dendroaspis angusticeps, D. polylepis and D. viridis. They are related to Kunitz-type inhibitors of serine proteases. Six natural variants have been sequenced: two isoforms of α-dendrotoxin and δ-dendrotoxin from D. angusticeps, toxin I and toxin K fromD. polylepis , and Dv 14 from D. viridis. Two related toxins, β- and...
Red Scorpio buthus tamulus enumeration lead to children death in India. Venom of the red scorpio (Buthus tamulus, BT) produces various cardiovascular and other abnormalities that can cause death. The underlying mechanisms are unknown, but other scorpion venoms contain toxins that affect ion channels and synaptic transmission. We, therefore, investigated the effects of BT on neuromuscular transmission...
Scorpion venoms contain toxins that block different types of potassium channels. Some of these toxins have affinity for high conductance Ca 2+ -activated K + channels and for dendrotoxin-sensitive voltage-dependent K + channels. The structural features that determine the specificity of binding to different channel types are not known. We investigated this using natural...
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