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Purpose
Glucose uptake and metabolism can be measured by chemical exchange–sensitive spin‐lock (CESL) MRI with an administration of glucose or its analogs. This study investigates the sensitivity, the spatiotemporal characteristics, and the signal source of glucoCESL with a 9L rat brain tumor model.
Methods
Dynamic CESL MRI with intravenous injection of D‐glucose, 2‐deoxy‐D‐glucose (2DG), and L‐glucose...
Recent proof-of-principle studies have demonstrated the feasibility of measuring the uptake and metabolism of non-labeled 2-deoxy-D-glucose (2DG) by a chemical exchange-sensitive spin-lock (CESL) MRI approach. In order to gain better understanding of this new approach, we performed dynamic in vivo CESL MRI on healthy rat brains with an intravenous injection of 2DG under various conditions at 9.4T...
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