Search results for: Bruce D. Spiess

Items from 1 to 20 out of 59 results

article

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment

Emmanuel K. Cudjoe, Zaneera H. Hassan, Le Kang, Penny S. Reynolds, more

Journal of Thrombosis and Haemostasis > 17 > 11 > 1827 - 1837

Background Fluid resuscitation plays a prominent role in stabilizing trauma patients with hemorrhagic shock yet there remains uncertainty with regard to optimal administration time, volume, and fluid composition (e.g., whole blood, component, colloids) leading to complications such as trauma‐induced coagulopathies (TIC), acidosis, and poor oxygen transport. Synthetic fluids in combination with antioxidants...

article

Vitamin B12 for the treatment of vasoplegia in cardiac surgery and liver transplantation: a narrative review of cases and potential biochemical mechanisms

Fritz-Gerald Charles, Leslie J. Murray, Christopher Giordano, Bruce D. Spiess

Canadian Journal of Anesthesia/Journal canadien d'anesthésie > 2019 > 66 > 12 > 1501-1513

Purpose Hydroxocobalamin, or vitamin B12 (V-B12), is frequently used to treat smoke inhalation and cyanide poisoning. Recent reports have also described its use to treat vasoplegia in cardiac surgery and liver transplantation. This narrative review discusses this “off-label” indication for V-B12, focusing on the potential biochemical mechanisms of its actions. Source PubMed, Cochrane, and Web of...

article

Anti‐N and anti‐Do^a immunoglobulin G alloantibody–mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC‐201: case report and review of the literature

Athira Unnikrishnan, J. Peter R. Pelletier, Shahla Bari, Marc Zumberg, more

Transfusion > 59 > 6 > 1907 - 1910

BACKGROUND Delayed hemolytic transfusion reaction (DHTR) with hyperhemolysis is a potentially fatal complication resulting from alloimmunization that can cause severe hemolysis of both transfused and intrinsic red blood cells (RBCs). Patients with sickle cell disease often receive multiple RBC units during their lifetime and thus are likely to develop alloantibodies that increase the risk for DHTR...

article

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

Alexander E. St. John, Jason C. Newton, Erika J. Martin, Bassem M. Mohammed, more

Journal of Thrombosis and Haemostasis > 17 > 5 > 771 - 781

Summary Background Trauma‐induced coagulopathy (TIC) is a common and deadly bleeding disorder. Platelet dysfunction is present during TIC, but its mechanisms remain unclear. Platelets are currently thought to become “exhausted,” a state in which they have released their granule contents and can no longer aggregate or contract. Methods This prospective observational cohort study tested the...

article

Hydroxocobalamin for the treatment of cardiac surgery-associated vasoplegia: a case series

Pranav R. Shah, Penny S. Reynolds, Nirvik Pal, Daniel Tang, more

Canadian Journal of Anesthesia/Journal canadien d'anesthésie > 2018 > 65 > 5 > 560-568

Purpose Vasoplegia is a clinical syndrome marked by severe arteriolar vasodilatation, hypotension, and low systemic vascular resistance refractory to multiple vasopressor treatment. We report our experience with hydroxocobalamin (B₁₂) infusion as a potential rescue adjunct for refractory vasoplegia during cardiopulmonary bypass (CPB). Methods We performed a retrospective chart review of 33 patients...

article

The Use of Topical Hemostatic Agents in Cardiothoracic Surgery

Art Bracey, Aryeh Shander, Solomon Aronson, Bradley A. Boucher, more

The Annals of Thoracic Surgery > 2017 > 104 > 1 > 353-360

Topical hemostatic agents are used in conjunction with conventional procedures to reduce blood loss. They are often used in cardiothoracic surgery, which is particularly prone to bleeding risks. Variation in their use exists because detailed policy and practice guidelines reflecting the current medical evidence have not been developed to promote best surgical practice in this setting. To address this...

article

Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned

Penny S. Reynolds, Mary J. Michael, Bruce D. Spiess

Trials > 2017 > 18 > 1 > 1-13

Background Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the ‘gold standard’ management system developed for managing diverse operations in major incident and public health arenas. It enables effective and flexible management through integration of personnel, procedures, resources,...

chapter

Percutaneous Cardiopulmonary Bypass As an Adjunctive Strategy for Resucitation

Catherine Cooper, Bruce D. Spiess

Contemporary Cardiology > Cardiopulmonary Resuscitation > 269-274

Cardiopulmonary bypass (CPB) is now 50 years old. Although developed originally to allow correction of congenital and valvular heart disease, CPB has affected all of medicine profoundly. As an artificial circulatory support for systemic and pulmonary functions, CPB has allowed for the development of cardiovascular surgery. Today, coronary artery bypass grafting is the most commonly performed cardiac...

article

Hextend–perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model

Penny S. Reynolds, Bruce D. Spiess

Journal of Surgical Research > 2015 > 199 > 2 > 536-544

Hextend (HEX) is standard of care resuscitation fluid for combat-related traumatic hemorrhage. Because HEX has limited oxygen-carrying capacity, combination therapy with oxygen therapeutics could improve oxygen delivery after hemodynamic shock. We hypothesized that addition of perfluorocarbon (PFC) to HEX would improve hemodynamics and oxygen delivery marker response in a rabbit model of hemorrhagic...

article

A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.

Joseph D. Roderique, Christopher S. Josef, Michael J. Feldman, Bruce D. Spiess

Toxicology > 2015 > 334 > Complete > 45-58

The first descriptions of carbon monoxide (CO) and its toxic nature appeared in the literature over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men ascribed the deleterious effects of this newly discovered gas to its strong interaction with hemoglobin. Since then the adverse sequelae of CO poisoning has been almost universally attributed to hypoxic injury secondary to...

article

Human Factors Analysis of a Near-Miss Event: Oxygen Supply Failure During Cardiopulmonary Bypass

Bruce D. Spiess, John Rotruck, Harry McCarthy, Olga Suarez-Wincosci, more

Journal of Cardiothoracic and Vascular Anesthesia > 2015 > 29 > 1 > 204-209

article

Prehospital use of plasma in traumatic hemorrhage (The PUPTH Trial): study protocol for a randomised controlled trial

Penny S. Reynolds, Mary Jane Michael, Emily D. Cochran, Jacob A. Wegelin, more

Trials > 2015 > 16 > 1 > 1-8

Background Severe traumatic injury and haemorrhagic shock are frequently associated with disruptions of coagulation function (such as trauma-induced coagulopathy TIC) and activation of inflammatory cascades. These pathologies may be exacerbated by current standard of care resuscitation protocols. Observational studies suggest early administration of plasma to severely-injured haemorrhaging patients...

article

Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro

Ivo P. Torres Filho, José Ricardo P. Pedro, Srinivasan V. Narayanan, Nguyen M. Nguyen, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 102 > 7 > 2105 - 2115

Perfluorocarbons (PFC) are compounds with high gas solubility that could help deliver O₂ to tissues and have been suggested as adjunct therapy to ischemia. Using a newly designed in vitro system, we tested the hypothesis that a third generation PFC emulsion (Oxycyte) increased O₂ transport of blood by measuring changes in O₂ extraction ratio. The system included a computer‐controlled pump and blood‐gas...

article

The Use of High-Dose Hydroxocobalamin for Vasoplegic Syndrome

Joseph D. Roderique, Kofi VanDyck, Brita Holman, Daniel Tang, more

The Annals of Thoracic Surgery > 2014 > 97 > 5 > 1785-1786

We describe a case of hypotension on cardiopulmonary bypass for coronary artery bypass grafting, double valve repairs, and patent foramen ovale closure. The patient experienced vasoplegic syndrome while on cardiopulmonary bypass. He was treated with high-dose hydroxocobalamin (vitamin B ₁₂ ). His blood pressure responded rapidly, obviating any further vasopressor requirements.

article

Effects of perfluorocarbon emulsions on microvascular blood flow and oxygen transport in a model of severe arterial gas embolism

Luciana N. Torres, Bruce D. Spiess, Ivo P. Torres Filho

Journal of Surgical Research > 2014 > 187 > 1 > 324-333

Arterial gas embolism (AGE) is a clinical problem that occurs directly in cardiopulmonary bypass machines in open-heart surgeries, or indirectly (through cardiac or pulmonary right to left shunts) in dive accidents, resulting in serious morbidity and even death. Perfluorocarbon (PFC) emulsions have been used for the treatment of AGE in an animal model. We hypothesized that PFC emulsions enhance microvascular...

article

Blood Transfusion and Infection After Cardiac Surgery

Bruce D. Spiess

The Annals of Thoracic Surgery > 2013 > 95 > 6 > 1855-1858

article

Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery

Damien J. LaPar, Ivan K. Crosby, Gorav Ailawadi, Niv Ad, more

The Journal of Thoracic and Cardiovascular Surgery > 2013 > 145 > 3 > 796-804

Efforts to reduce blood product use have the potential to avoid transfusion-related complications and reduce health care costs. The purpose of this investigation was to determine whether a multi-institutional effort to reduce blood product use affects postoperative events after cardiac surgical operations and to determine the influence of perioperative transfusion on risk-adjusted outcomes.A total...

article

Aprotinin revisited

Abe DeAnda, Bruce D. Spiess

The Journal of Thoracic and Cardiovascular Surgery > 2012 > 144 > 5 > 998-1002

In 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to decrease postoperative bleeding and complications. The Canadian study raised questions previously brought up in similar studies—does aprotinin increase...

article

In vivo microvascular mosaics show air embolism reduction after perfluorocarbon emulsion treatment

Ivo P. Torres Filho, Luciana N. Torres, Bruce D. Spiess

Microvascular Research > 2012 > 84 > 3 > 390-394

Massive arteriolar gas embolism (AGE) has never been evaluated in vivo using intravital microscopy and previous perfluorocarbon (PFC) emulsions were only effective in AGE when administered before AGE. We implemented a new system for quantitative studies of massive AGE using brightfield microscopy and tested a treatment with a third-generation PFC emulsion after massive AGE. We studied bubble dynamics...

article

Pro: The Practice of Cardiac Anesthesia Has Changed After the Withdrawal of Aprotinin

Bruce D. Spiess

Journal of Cardiothoracic and Vascular Anesthesia > 2010 > 24 > 5 > 875-878

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Bruce D. Spiess

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment

Vitamin B12 for the treatment of vasoplegia in cardiac surgery and liver transplantation: a narrative review of cases and potential biochemical mechanisms

Anti‐N and anti‐Do^a immunoglobulin G alloantibody–mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC‐201: case report and review of the literature

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

Hydroxocobalamin for the treatment of cardiac surgery-associated vasoplegia: a case series

The Use of Topical Hemostatic Agents in Cardiothoracic Surgery

Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned

Percutaneous Cardiopulmonary Bypass As an Adjunctive Strategy for Resucitation

Hextend–perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model

A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.

Human Factors Analysis of a Near-Miss Event: Oxygen Supply Failure During Cardiopulmonary Bypass

Prehospital use of plasma in traumatic hemorrhage (The PUPTH Trial): study protocol for a randomised controlled trial

Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro

The Use of High-Dose Hydroxocobalamin for Vasoplegic Syndrome

Effects of perfluorocarbon emulsions on microvascular blood flow and oxygen transport in a model of severe arterial gas embolism

Blood Transfusion and Infection After Cardiac Surgery

Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery

Aprotinin revisited

In vivo microvascular mosaics show air embolism reduction after perfluorocarbon emulsion treatment

Pro: The Practice of Cardiac Anesthesia Has Changed After the Withdrawal of Aprotinin

Filter options

Publication date

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Bruce D. Spiess

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options