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Lysosomes have traditionally been viewed as degradative organelles, although a growing body of evidence suggests that they can function as Ca2+ stores. Here we examined the function of these stores in hippocampal pyramidal neurons. We found that back-propagating action potentials (bpAPs) could elicit Ca2+ release from lysosomes in the dendrites. This Ca2+ release triggered the fusion of lysosomes...
A rise in [Ca 2+ ] i provides the trigger for neurotransmitter release at neuronal boutons. We have used confocal microscopy and Ca 2+ sensitive dyes to directly measure the action potential-evoked [Ca 2+ ] i in the boutons of Schaffer collaterals. This reveals that the trial-by-trial amplitude of the evoked Ca 2+ transient is bimodally distributed....
Boutons are specialised presynaptic compartments that lie along the axons of central neurons. Release of neurotransmitter from boutons is tightly regulated by the level of intracellular calcium [Ca 2+ ] i . A rise in Ca 2+ level may be generated in several ways; entry of extracellular Ca 2+ via voltage gated calcium channels (VGCCs), entry via ligand-operated channels...
The expression mechanism of long-term potentiation (LTP) remains controversial. Here we combine electrophysiology and Ca 2+ imaging to examine the role of silent synapses in LTP expression. Induction of LTP fails to change p r at these synapses but instead mediates an unmasking process that is sensitive to the inhibition of postsynaptic membrane fusion. Once unmasked, however, further...
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