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We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc=tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hydroxy ketones in good yield. The key reagents of this reaction are the difluoroenol O-Boc esters, which are easily synthesized from trifluoromethyl alcohols in...