Search results for: Jeonghan Kim

Items from 1 to 17 out of 17 results

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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

Sung-Jun Park, Oksana Gavrilova, Alexandra L. Brown, Jamie E. Soto, more

Cell Metabolism > 2017 > 26 > 2 > 447

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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

Sung-Jun Park, Oksana Gavrilova, Alexandra L. Brown, Jamie E. Soto, more

Cell Metabolism > 2017 > 25 > 5 > 1135-1146.e7

Hallmarks of aging that negatively impact health include weight gain and reduced physical fitness, which can increase insulin resistance and risk for many diseases, including type 2 diabetes. The underlying mechanism(s) for these phenomena is poorly understood. Here we report that aging increases DNA breaks and activates DNA-dependent protein kinase (DNA-PK) in skeletal muscle, which suppresses mitochondrial...

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Characterizing local structure of SiOx using confocal μ-Raman spectroscopy and its effects on electrochemical property

Sunyoung Yoo, JeongHan Kim, Byoungwoo Kang

Electrochimica Acta > 2016 > 212 > C > 68-75

We use confocal μ-Raman spectroscopy to characterize the local microstructure of SiO_x particles that are composed of amorphous and crystalline phase and to understand its effects on electrochemical reactions. Particles of bare SiO_x (x∼1) consist of an inhomogeneous mixture of a-Si and c-Si; some particles mainly have a-Si phase but others consist mainly of micro-sized crystalline Si phase. In contrast,...

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14-3-3β and γ differentially regulate peroxisome proliferator activated receptor γ2 transactivation and hepatic lipid metabolism

Sodam Park, Seungmin Yoo, Jeonghan Kim, Hyoung-Tae An, more

BBA - Gene Regulatory Mechanisms > 2015 > 1849 > 10 > 1237-1247

Peroxisome proliferator activated receptor (PPAR) γ₂ plays important roles in glucose and lipid metabolism in hepatocytes. PPARγ₂ is involved in metabolic disorders, including obesity, diabetes, and fatty liver disease. Although the 14-3-3 proteins participate in a variety of cell signal pathways, the roles of the 14-3-3 proteins in regulating PPARγ₂ transactivation and hepatic lipid metabolism are...

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The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis

Jeonghan Kim, Sung-Wuk Jang, Eunsoo Park, Minseok Oh, more

Journal of Molecular and Cellular Cardiology > 2014 > 72 > C > 157-167

The molecular chaperone heat shock protein 90 (HSP90) is overexpressed in plaques of atherosclerosis patients, and is associated with plaque instability. However, the role of HSP90 in atherosclerosis remains unclear. The present study investigated the effects of HSP90 inhibition on migration and proliferation of vascular smooth muscle cells (VSMCs) and involvement in atherosclerosis. To examine the...

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N-acetyl cysteine suppresses the foam cell formation that is induced by oxidized low density lipoprotein via regulation of gene expression

Ho Joong Sung, Jeonghan Kim, Yoonseo Kim, Sung-Wuk Jang, more

Molecular Biology Reports > 2012 > 39 > 3 > 3001-3007

Foam cells derived from macrophages have been implicated as markers of early stage atherosclerosis development. In this study, we found that N-acetyl cysteine (NAC), a well-known inhibitor of reactive oxygen species (ROS), decreased the generation of ROS and suppressed foam cell formation in the presence of oxidized low density lipoprotein through down-regulation of cluster of differentiation 36 expression...

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Effects of (NH4)2SO4 and BTA on the nanostructure of copper foam prepared by electrodeposition

DoHwan Nam, RyoungHee Kim, DongWook Han, JeongHan Kim, more

Electrochimica Acta > 2011 > 56 > 25 > 9397-9405

Copper foam with dendritic copper nanostructure was synthesized by an electrodeposition process using hydrogen bubbles as dynamic templates. To modify the morphology of the copper nanostructure in the foam walls, (NH ₄ ) ₂ SO ₄ and BTA (benzotriazole) were introduced into the electrolytic bath as chemical additives, and their influences on the morphologies and the structural...

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CKβ8/CCL23 and its isoform CKβ8-1 induce up-regulation of cyclins via the Gi/Go protein/PLC/PKCδ/ERK leading to cell-cycle progression

Jeonghan Kim, Yoon Suk Kim, Jesang Ko

Cytokine > 2010 > 50 > 1 > 42-49

CKβ8/CCL23 is a CC chemokine and alternative splicing of the CKβ8 gene produces two mRNAs that encode CKβ8 and its isoform CKβ8-1. Chemokines play a critical role in leukocyte trafficking and development of inflammation and chemokines are also known to be involved in cell proliferation. To investigate participation of CKβ8 and CKβ8-1 in cell proliferation, we examined the effects of CKβ8 and CKβ8-1...

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CKβ8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKCδ/NF-κB and is involved in inflammatory responses

Jeonghan Kim, Yoon Suk Kim, Jesang Ko

Life Sciences > 2010 > 86 > 9-10 > 300-308

CKβ8/CCL23 is a CC chemokine and alternative splicing of the CKβ8 gene produces two mRNAs that encode CKβ8 and its isoform CKβ8-1. Although it has been reported that CKβ8 and CKβ8-1 are implicated in leukocyte trafficking and development of inflammation, the exact roles of these two chemokines in immune responses and the associated chemotaxis signaling are still obscure.To understand the mechanism...

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The role of calpains in ligand-induced degradation of the glucocorticoid receptor

Yoon Suk Kim, Jeonghan Kim, Yoonseo Kim, Young Han Lee, more

Biochemical and Biophysical Research Communications > 2008 > 374 > 2 > 373-377

The glucocorticoid receptor (GR) is a ligand-activated transcription factor that mediates the effects of glucocorticoids in diverse cellular processes, including homeostasis, stress response, and inflammation. Glucocorticoids induce down-regulation of GR at both the mRNA and protein levels, causing reduced hormone responsiveness in response to long-term treatment with glucocorticoid. However, the...

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Direct force measurement between cucurbit[6]uril and spermine using atomic force microscopy

Jeonghan Kim, Youngkook Kim, Kangkyun Baek, Young Ho Ko, more

Tetrahedron > 2008 > 64 > 36 > 8389-8393

The rupture forces of individual host–guest complexes between surface-confined cucurbit[6]uril (CB[6]) and spermine derivatives were measured directly by atomic force microscopy (AFM). While 1,2-dithiolane-attached spermine was immobilized on a gold-coated AFM tip, perallyloxyCB[6] was attached to an allyl-terminated self-assembled monolayer on a gold substrate by olefin metathesis reaction. A histogram...

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Investigation of laser remote welding using disc laser

Cheolhee Kim, Junghak Kim, Hyunsik Lim, Jeonghan Kim

Journal of Materials Processing Tech. > 2008 > 201 > 1-3 > 521-525

Laser remote welding techniques are used to enhance the flexibility of laser welding process and remote welding systems based on solid-state lasers and robots are of special interest to the automotive. There are two concepts available to implement laser remote welding—the scanner-integrated system and the robot-based system. The scanner-integrated system utilizes a 2- or 3-axis optical unit for bead...

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Titanium complexes: A possible catalyst for controlled radical polymerization

Young-Je Kwark, Jeonghan Kim, Bruce M. Novak

Macromolecular Research > 2007 > 15 > 1 > 31-38

Pentamethylcyclopentadienyltitanium trichloride, bis(cyclopentadienyl)titanium dichloride (Cp₂TiCl₂), and bis(pentamethylcyclopentadienyl)titanium dichloride were used in the polymerization of styrene without the aid of Group I–III cocatalysts. The properties of the resulting polymer indicated that polymerization was more controlled than in thermal polymerization. The kinetic studies indicated that...

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RRC unnecessary for DGPS messages

Byungwoon Park, Jeonghan Kim, Changdon Kee, Cleveland, A., more

IEEE Transactions on Aerospace and Electronic Systems > 2006 > 42 > 3 > 1149 - 1160

The range rate correction (RRC) was useful in reducing the latency error of pseudo-range correction (PRC), and the data baud rate. With selective availability (SA) removed, the temporal variations in the corrections are much smaller, so the issue has been raised as to whether the RRC term is still necessary. We provide results on PRC and RRC variation that account for seasonal, diurnal, and regional...