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Despite the known association of several genes to clinical Isoniazid (INH) resistance, its molecular basis remains unknown in ∼16% of clinical isolates of Mycobacterium tuberculosis (M. tb). While screening a set of Mycobacterium smegmatis (M. smegmatis) transposon mutants with altered colony morphology for differential susceptibility to INH, we found six resistant mutants and mapped their transposon...