Search results for: César Muñoz-Fontela

Items from 1 to 9 out of 9 results

article

Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report

Jennifer Cable, Anthony Fauci, William E. Dowling, Stephan Günther, more

Annals of the New York Academy of Sciences > 1518 > 1 > 209 - 225

The COVID‐19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10–13, 2022, researchers across academia, industry, government, and nonprofit organizations met at the Keystone symposium “Lessons from the Pandemic: Responding to Emerging Zoonotic Viral Diseases” to discuss the successes and challenges of the COVID‐19 pandemic and what lessons can be...

article

Monocyte‐derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8⁺ T‐cell immunodominance

Jazmina L. G. Cruz, José V. Pérez‐Girón, Anja Lüdtke, Sergio Gómez‐Medina, more

European Journal of Immunology > 47 > 2 > 345 - 352

Influenza virus infection triggers an increase in the number of monocyte‐derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8⁺ T cells and trigger the switch in immunodominance of the CD8⁺ T‐cell response from acidic polymerase specificity...

article

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus

Xuan Liu, Emily Speranza, César Muñoz-Fontela, Sam Haldenby, more

Genome Biology > 2017 > 18 > 1 > 1-17

Background In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with...

article

Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase

Dennis Tappe, José Vicente Pérez-Girón, Lorenzo Zammarchi, Jürgen Rissland, more

Medical Microbiology and Immunology > 2016 > 205 > 3 > 269-273

Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here,...

article

Zika virus infections imported to Italy: Clinical, immunological and virological findings, and public health implications

Lorenzo Zammarchi, Giulia Stella, Antonia Mantella, Dario Bartolozzi, more

Journal of Clinical Virology > 2015 > 63 > Complete > 32-35

We report the first two cases of laboratory confirmed Zika virus (ZIKV) infections imported into Italy from French Polynesia. Both patients presented with low grade fever, malaise, conjunctivitis, myalgia, arthralgia, ankle oedema, and axillary and inguinal lymphadenopathy. One patient showed leukopenia with relative monocytosis and thrombocytopenia.The diagnosis was based on ZIKV seroconversion in...

article

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

Lisa Oestereich, Anja Lüdtke, Stephanie Wurr, Toni Rieger, more

Antiviral Research > 2014 > 105 > Complete > 17-21

Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use in humans. Here, we evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo. T-705 suppressed replication of Zaire EBOV in...

article

P114 Modulation of vaccine-induced T cell immunity by specific adjuvants

V. Perez-Giron, Alan Belicha-Villanueva, Sergio Gomez-Medina, Stefanie Ahrens, more

Cytokine > 2012 > 59 > 3 > 555-556

Successful vaccination requires generation of long-lasting and protective T cell responses, and thus, therapeutic strategies aimed to enhance vaccine-induced T cell immunity are a source of great interest. Here we have investigated the influence of toll-like receptor (TLR)-3 ligands as well as type I interferon (IFN) agonists on the maintenance of CD8 ⁺ T cell memory in the context of mucosal...

article

292 p53 Transcriptionally activates IRF9 to enhance antiviral immunity

César Muñoz-Fontela, Salvador Macip, Luis Martínez-Sobrido, Rana Elkholi, more

Cytokine > 2008 > 43 > 3 > 312-313

article

FLUTAX facilitates visualization of the ciliature of oxytrichid hypotrichs

Lucía Arregui, César Muñoz-Fontela, Almudena Guinea, Susana Serrano

European Journal of Protistology > 2003 > 39 > 2 > 169-172

The fluorescent taxoid FLUTAX that specifically binds to microtubules was employed to stain cells of the oxytrichid ciliate Sterkiella cavicola. Due to their cortical peculiarities, ciliates of this group have traditionally been difficult to stain, and in consequence their identification presents uncertainty. Here, a variant of the employment of FLUTAX is proposed with the aim of simplifying the visualization...

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