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3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an important precursor of the major brain metabolites of dopamine, 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxy-phenylacetic acid. A new method for the synthesis of DOPAL from piperonal is described. We report for the first time the physical and chemical characteristics of DOPAL. Its importance for research in Parkinson's disease and Alzheimer's...
Trideuterated 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL-d 3 ) was synthesized from tetradeuterated catechol. After derivatization withN-methyl-N-trimethylsilyltrifluoroacetamide, the identity of DOPEGAL-d 3 was confirmed by comparison with unlabeled DOPEGAL by gas chromatography–mass spectrometry (GC–MS); they have the same pattern of mass fragmentation. The deuterated DOPEGAL was...