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High maternal uric acid serum levels are often associated with preeclampsia. The regulation of the placental uric acid transport system and its major uric acid transporter, glucose transporter 9 (GLUT9) are not fully understood yet. We hypothesized that the lack of GLUT9 in the placenta leads to exposure of high uric acid levels in the fetus.Using a systemic GLUT9 knockout mice model we aim to understand...
Transplacental fetal glucose supply is predominantly regulated by glucose transporter-1 (GLUT1). Altered expression and/or function of GLUT1 may affect the intrauterine environment, which could compromise fetal development and may contribute to fetal programming. To date it is unknown whether placental GLUT1 is affected by preeclampsia, which is often associated with intrauterine growth restriction...
Prosenescence therapy has recently emerged as a novel therapeutic approach for treating cancer. However, this concept is challenged by conflicting evidence showing that the senescence-associated secretory phenotype (SASP) of senescent tumor cells can have pro- as well as antitumorigenic effects. Herein, we report that, in Pten-null senescent tumors, activation of the Jak2/Stat3 pathway establishes...
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