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TNF-α, a polypeptide secreted by macrophages has been shown to have a regulatory effect on ovarian function by attenuating the differentiation of granulosa cells through neutralization of follicle stimulating hormone (FSH) and decreasing leutinizing hormone stimulated progesterone production. TNF-α in women with endometriosis, may cause luteolysis and cytotoxicity against spermatozoa. Potential...